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Pastime

The a16z Show

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

Oct 03 2026 | 00:48:17

A16z’s Erik Torenberg sits down with OpenRouter’s Alex Atallah and Replit founder and CEO Amjad Masad to discuss why the future of AI may look less like one all-purpose model and more like an ecosystem of specialized models working together.

Alex explains why OpenRouter is betting on “neurodiversity”: different models trained in different ways, routed and combined based on the job at hand. Amjad makes a similar case from inside the enterprise, where companies increasingly need to own their AI capabilities rather than depend entirely on a single model provider. 

They explore what happens when general-purpose agents give way to teams of specialized agents, why smaller models can sometimes be cheaper, safer, and easier to control, and how routing and model fusion could deliver frontier-level performance at lower cost. They also get into agent-to-agent communication, AI security, and why the next generation of companies may need an independence layer across models, clouds, and data.


Resources:

Follow Alex Atallah on X: https://x.com/alexatallah

Follow Amjad Masad on X: https://x.com/amasad

Learn more about OpenRouter: https://openrouter.ai

Learn more about Replit: https://replit.com

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Oct 02 2026 | 00:59:48

a16z’s Seema Amble and Elena Burger sit down with Lio co-founder and CEO Vladimir Keil to ask where AI-native startups have an advantage when incumbent software companies already own the customer, the data, and the system of record.

Their answer comes down to the work that happens outside those systems. In procurement, a final price in an ERP can hide hundreds of emails, spreadsheets, supplier conversations, engineering analyses, and decisions across legal, finance, and operations. Vlad explains how Lio uses multi-agent systems to take on more of that end-to-end work, from sourcing and RFQs to negotiation, shipment tracking, and invoices.

They also discuss how enterprises learn to trust agents with increasingly consequential decisions, why the last 20% of an internal AI build can require most of the effort, and what happens when both buyers and suppliers have agents working on their behalf.


Resources:

Follow Vladimir Keil on X: https://x.com/askvladi?lang=en 

Follow Vladimir Keil on LinkedIn: https://www.linkedin.com/in/vladimir-keil/

Follow Seema Amble on X: https://x.com/seema_amble 

Learn more about Lio: https://www.lio.ai/ 

Seema Amble’s “Investing in Lio” article: https://a16z.com/announcement/investing-in-lio/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Oct 01 2026 | 00:45:23

a16z’s Joel de la Garza sits down with DoxxNet founder Barrett Lyon to discuss what it would take to rebuild the internet around privacy, direct communication, and less dependence on centralized intermediaries.

Barrett explains why he thinks traditional VPNs only solve part of the problem and how DoxxNet is building a parallel mesh network where users can communicate peer-to-peer, transfer large files, make calls, and message without routing those interactions through a central application server. He also explains why the company owns its infrastructure and runs its AI systems locally rather than relying on third-party inference providers. doxxnet_assembly

They also get into the growing amount of tracking embedded across the internet, what happens when that data can be analyzed by increasingly capable AI, and why Barrett believes the underlying protocols of the internet are due for another wave of experimentation. Along the way, he shares lessons from decades of building internet infrastructure, from fighting early DDoS attacks to mapping the internet and building global networks.


Resources:

Learn more about DoxxNet: https://doxx.net

Follow Barrett Lyon on X: https://x.com/BarrettLyon

Follow Joel de la Garza on LinkedIn: linkedin.com/in/3448827723723234

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 30 2026 | 00:53:38

a16z’s David George, Sarah Wang, Alex Immerman, and Santiago Rodriguez unpack 25 key charts from the latest State of Markets presentation, from the scale of the AI infrastructure buildout to what adoption looks like inside companies today.

They examine why rising markets have so far been supported by earnings rather than multiple expansion, why hyperscaler CapEx is approaching $1 trillion annually, and why demand for compute continues to outrun supply. They also look at the downstream effects of that spending across chips, power, construction, and physical infrastructure. State of Markets

Then they move up the stack: OpenAI and Anthropic’s revenue growth, the gap between AI deployment and measurable enterprise impact, the rise of agents, falling inference costs, and what all of this means for SaaS. They close with where the team is spending time next, including consumer agents, robotics, autonomy, AI and biology, personal health, defense, and the continued diffusion of AI across the enterprise. State of Markets


Resources:

Follow David George on X: https://x.com/DavidGeorge83

Follow Sarah Wang on X: https://x.com/sarahdingwang

Follow Alex Immerman on X: https://x.com/aleximm 

Follow Santiago Rodriguez on X: https://x.com/santiago__rdz 

Read David’s piece ‘There are only two paths left for software’: https://a16z.com/there-are-only-two-paths-left-for-software/

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 29 2026 | 00:51:27

a16z General Partner Anish Acharya sits down with Assistant Benchmark creator David Pawlan to unpack the sudden explosion of personal AI agents and what it will take for one to become part of everyday life.
David has been testing dozens of assistants across real-world tasks, from managing email and booking travel to handling financial admin. They discuss why the most useful agents may become increasingly invisible, proactively checking you into flights, finding refunds, filing reimbursements, or simply handling the small tasks that pile up across everyday life.
They also explore whether the winning interface is an app, text thread, voice, or wearable; how much autonomy consumers will actually give their agents; and what happens when agents start interacting with other agents. From commerce and restaurant reservations to entirely new agent-native services, Anish and David ask what the internet looks like when software starts acting on our behalf.

This episode was recorded on September 24, 2026.

 

Resources:

Follow David Pawlan on X: https://x.com/DavidPawlan

Follow Anish Acharya on X: https://x.com/illscience


 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 28 2026 | 00:43:14

a16z’s Ben Horowitz and Martin Casado sit down with TypeSafe AI founder Diogo Almeida to ask a simple question: AI has become remarkably capable, so where is all the automation?

Diogo argues that coding agents may help us write software faster, but the software they produce still largely works the way software always has. TypeSafe is taking a different approach with Jev: putting intelligence inside software itself, so developers can build programs that reason about intent and make probabilistic decisions rather than simply generate text for a human to interpret.

They discuss why reliability is the key to making AI genuinely programmable, how this could open a new era of probabilistic software, and why established SaaS companies may be particularly well positioned to benefit. Ultimately, Diogo’s goal is straightforward: technology that can reliably “do what I mean.”


Resources:

Follow Diogo Almeida: https://x.com/CompleteSkeptic

Learn more about TypeSafe AI: https://typesafe.ai/

Follow TypeSafe AI: https://x.com/typesafeai

Follow Ben Horowitz on X: https://x.com/bhorowitz

Follow Martin Casado on X: https://x.com/martin_casado

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 27 2026 | 00:48:08

a16z’s Katie Kirsch sits down with Harvey VP of Talent Maggie Landers to discuss what happens inside a company growing at AI speed, and how you preserve culture while adding more than 1,000 employees in a year.

Maggie explains why Harvey prioritizes progress over perfection, how its values of simplicity, decisiveness, and “job’s not finished” shape the way people work, and why moving quickly requires giving employees significant trust and autonomy. For people accustomed to being the “A student,” that can mean learning to experiment, make mistakes, and course-correct quickly.

They also get into how Harvey identifies people who can thrive in that environment, what changes when most of your company is relatively new, the role its founders play in maintaining culture, and why judgment becomes increasingly important when employees are given the freedom to move fast.


Resources:

Follow Maggie Landers on LinkedIn: linkedin.com/in/maggiecohenlanders

Follow Katie Kirsch on X: https://x.com/katiekirsch

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 26 2026 | 00:56:00

Erik Torenberg sits down with Box CEO Aaron Levie, and a16z’s Martin Casado, and Steven Sinofsky to debate how the AI industry should think about safety, security, and regulation as increasingly capable agents move into the real world.

They argue that much of today’s conversation is happening before we have clearly defined the risks we’re trying to regulate. Drawing on earlier waves of computing, from computer viruses and the early internet to aviation and automobiles, they ask what AI can learn from industries that developed safety standards only after understanding how their technologies actually failed.

The conversation then gets concrete: agents don’t get tired, can operate at enormous scale, and can probe systems in ways human employees never could. That could require rethinking permissions, authentication, operating systems, and the security stack itself. They also discuss why AI innovation may increasingly move beyond the frontier labs and into the software built around the models.


Resources:

Follow Aaron Levie on X: https://x.com/levie

Follow Martin Casado on X: https://x.com/martin_casado

Follow Steven Sinofsky on X: https://x.com/stevesi

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 25 2026 | 00:50:23

a16z’s Erik Torenberg sits down with Josh Elman, Olivia Moore, and David Booth to introduce Cosign, a new product built around professional reputation and the people, companies, and products you’re willing to put your name behind.

They unpack a simple idea at the heart of Silicon Valley: some of the most valuable professional signals aren’t credentials, but who believes in you. From the mentor who shaped your career to the colleague you’d work with anywhere or the young builder you think everyone should be watching, Cosign is an attempt to make those signals more visible and durable.

They also discuss why human endorsements may become more valuable as AI makes outreach and information abundant, what existing professional networks get right and miss, and how making reputation more legible could help talented people get discovered earlier, find collaborators, and carry the work they’ve done behind the scenes into whatever they do next.


Resources:

Follow Josh Elman on X: https://x.com/joshelman

Follow Olivia Moore on X: https://x.com/omooretweets

Follow David Booth on X: https://x.com/david__booth

Follow Cosign: https://x.com/cosign_build

Read more about Cosign: https://www.a16z.news/how-silicon-valley-knows-its-people

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 24 2026 | 00:27:49

a16z crypto General Partner Eddy Lazzarin joins Theo Jaffee on MTS to debate the increasingly prominent calls to slow AI development and whether the current safety conversation is conflating very different kinds of risk.

Eddy argues that the debate puts too much emphasis on speculative superintelligence and not enough on the costs of delaying useful technology. Rather than treating every AI failure as evidence of an alignment problem, he makes the case for familiar tools like cybersecurity, accountability, liability, market incentives, and stronger technical controls.

They also discuss whether AI models can develop reputations for trustworthiness, the risks of concentrating oversight among a small group of evaluators, and why Eddy thinks the collision between Silicon Valley’s AI debates and broader politics could fundamentally reshape the conversation over the next year.


Resources:

Follow Eddy Lazzarin on X: https://x.com/eddylazzarin

Follow Theo Jaffee on X: https://x.com/theojaffee

Follow MTS on X: https://x.com/mtslive

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 23 2026 | 00:47:47

Erik Torenberg sits down with Replit founder and CEO Amjad Masad and Horowitz and Andreessen Academy co-founder and CEO Gagan Biyani to ask what education should look like for a generation growing up with AI.

Amjad argues that one of the most valuable things young people bring to society is their willingness to question deeply held assumptions. They discuss how education could create more room for that instinct through project-based learning, intellectual side quests, and giving students the freedom to follow an idea deeply rather than optimizing around grades and credentials.

They also explore whether young founders are being pushed to professionalize too early, why Amjad thinks starting a company can sometimes be a form of “premature optimization,” and how curiosity led him from learning chess to experimenting with AI that can conduct machine-learning research.

Finally, they discuss trust, judgment, and what it means to develop as a person, not just a builder, including why being contrarian and ambitious still needs to be balanced with the ability to work with other people.


Resources:

Follow Amjad Masad on X: https://x.com/amasad

Follow Gagan Biyani on X: https://x.com/gaganbiyani
 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 22 2026 | 00:43:02

Ben Horowitz and Erik Torenberg sit down with Gagan Biyani to introduce the Horowitz and Andreessen Academy and discuss a bigger question: what should education look like when AI is rapidly changing the skills people need to build, work, and create?

Ben and Gagan explain why they believe learning should be more focused on doing rather than studying about doing, with students building real projects, developing people skills, and working alongside companies and builders in San Francisco. The goal isn’t to replace college for everyone, but to create a different path for young people who already know they want to build.

They also discuss why AI could make this an unusually powerful time to be young, how project-based learning changes when everyone has access to powerful tools, why failure can be valuable when it produces real learning, and what it takes to develop the judgment and people skills that can't simply be learned from a textbook.


Resources:

Follow Gagan Biyani on X: https://x.com/gaganbiyani

Follow Ben Horowitz on X: https://x.com/bhorowitz
 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 21 2026 | 00:29:02

a16z Board Partner and former Microsoft Windows president Steven Sinofsky joins Theo Jaffee and Sofia Puccini on MTS to argue that the language we use to describe AI failures is making it harder to understand what’s actually going wrong.

Steven takes aim at terms like “alignment,” “goal-seeking,” and “rogue agents,” arguing that they can anthropomorphize problems that software engineers have dealt with for decades. His framing is simpler: when software doesn’t do what it’s supposed to do, it has a bug. And as AI becomes more widely deployed, labs need the same kind of telemetry, debugging, incident reporting, and operational discipline that previous generations of software eventually developed.

Drawing on everything from early computer hacking and Microsoft’s response to major software failures to Y2K and cybersecurity standards, Steven makes the case for treating AI reliability as an engineering problem. They also discuss what AI labs can learn from CVE reporting, why industry has a responsibility to make its systems safer, and how confusing terminology can lead to equally confused regulation.


Resources:

Follow Steven Sinofsky on X: https://x.com/stevesi

Follow Theo Jaffee on X: https://x.com/theojaffee

Follow Sofia Puccini on X: https://x.com/schisofrenia

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 20 2026 | 00:57:18

Ben Horowitz and Erik Torenberg sit down with Nas, Grandmaster Caz, and Steve Stoute for a conversation about the Paid in Full Foundation and its mission to recognize and support the pioneers who built hip-hop.

Ben, Nas, and Steve share how the foundation began, why simply giving artists money wasn’t enough, and how the Hip Hop Grandmaster Awards became a way to pair financial support with the recognition many foundational artists never received. Caz brings the perspective of one of those pioneers, reflecting on his role in hip-hop’s earliest history and what receiving the award has meant for his life and legacy.

They also discuss the enormous cultural and commercial impact of hip-hop beyond music, from language and fashion to some of the world’s biggest brands, why so many of its pioneers captured so little of that value, and what happens when generations of hip-hop finally come together in the same room.


Resources:

Learn more about the Paid in Full Foundation: https://paidinfullfoundation.org

Follow Nas on X: https://x.com/Nas

Follow Grandmaster Caz on IG:https://www.instagram.com/grandmastercaz07/

Follow Steve Stoute: https://linkedin.com/in/stevestoute

Follow Ben Horowitz on X: https://x.com/bhorowitz

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 19 2026 | 01:00:18

a16z Partner Josh Elman joins Ollie Forsyth on New Economies to discuss the next wave of consumer AI and what separates a product people try once from one that becomes part of their everyday lives.

Josh argues that getting attention has actually become easier, but getting consumers to stick is harder than ever. He explains what he looks for in consumer products, why the best ones start with a narrow wedge and earn the right to do more, and why trust becomes increasingly important as AI agents gain access to more of our personal lives.

They also explore personal AI agents, the future of shopping and entertainment, why we haven’t seen another major social network emerge, and how AI could make technology more social rather than less, including agents that help people spend more time together in the real world.

This conversation originally appeared on the New Economies podcast.


Resources:

Follow Josh Elman on X: https://x.com/jelman

Follow New Economies: https://www.youtube.com/@NEWECONOMIESPOD

New Economies Substack: https://www.neweconomies.co/


 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 18 2026 | 01:08:34

Databricks co-founder and CEO Ali Ghodsi joins a16z General Partners Martin Casado and Sarah Wang for a conversation about AI risk, recursive self-improvement, cybersecurity, and what’s actually holding back enterprise adoption.

Ali argues that today’s models are already capable enough to automate far more work than most companies are using them for. The bigger problem is context: models haven’t been in every meeting, don’t understand how decisions actually get made, and lack the institutional knowledge that experienced employees accumulate over years. He explains why building an organizational “ontology” could help close that gap and what Databricks has learned from doing it internally.

They also debate the current conversation around pacing frontier AI, what would constitute meaningful recursive self-improvement, and why Ali distinguishes speculative superintelligence risk from the much more immediate challenge of AI-powered cyberattacks. They close with how enterprises are managing exploding AI usage and costs, the shift toward multiple models and harnesses, and why agents are beginning to reshape infrastructure itself.

 

Resources:

Follow Ali Ghodsi on X: https://x.com/alighodsi

Follow Sarah Wang on X: https://x.com/sarahdingwang

Follow Martin Casado on X: https://x.com/martin_casado
 

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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.


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Sep 17 2026 | 00:39:32

a16z General Partner Jennifer Li sits down with fal co-founder Gorkem Yurtseven and Head of Engineering Batuhan Taskaya to discuss what changes when generative video becomes fast enough to run in real time.

They unpack the technical work behind H3 Max, fal’s post-trained version of MiniMax’s open-weight video model, and how combining model post-training with systems and hardware optimization significantly reduced generation time while maintaining quality. That speed has enabled experiments with continuous video, including streams that can remember previous scenes and respond to new directions while they’re running.

They also discuss why the next challenge may be less about speed and more about control, from camera movement and lighting to characters, motion, and lip sync. And they explore what those capabilities could mean for professional creative workflows, where artists and studios need predictable tools rather than simply generating a video from a prompt.


Resources:

Follow Gorkem Yurtseven on X: https://x.com/gorkem

Follow Batuhan Taskaya on X: https://x.com/isidentical

Learn more about fal: https://fal.ai

Follow Jennifer Li on X: https://x.com/JenniferHli


 

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Sep 16 2026 | 00:52:43

a16z’s Alex Rampell and Joe Schmidt sit down with Lightfield co-founder and CEO Keith Peiris to discuss what it takes to rethink the CRM for an AI-native world, and the unusual pivot that got him there.

Keith previously built Tome to 25 million users, but eventually walked away from the product after concluding that the underlying technology couldn’t capture enough context about a presenter, their audience, and the relationship between them. Starting again, his team followed customers from AI presentations into sales workflows and eventually found a harder problem: making sense of the fragmented and often conflicting data spread across a company’s emails, calls, CRM, and other systems.

They unpack Lightfield’s idea of a “business world model,” why Keith believes intelligence can replace much of the rigid schema behind traditional software, and what changes when AI has enough context to reason about a company and its customers. They also get into building for greenfield versus brownfield markets, AI-era pricing, running a company where everyone is a generalist, and Keith’s lessons from making a hard pivot.


Resources:

Follow Keith Peiris on LinkedIn: https://www.linkedin.com/in/keithpeiris

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Learn more about Lightfield: https://lightfield.app

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Sep 15 2026 | 00:42:39

Elena Burger sits down with academic and cyber ethnographer Ruby Justice Thelot to explore the increasingly blurry line between internet culture and the real world, and how to tell the difference between a trend that’s actually changing behavior and one that simply feels enormous online.

They use today’s wellness and optimization culture as a case study, from peptides and GLP-1s to protein maxxing, wearables, microplastics, and the quantified self. Ruby explains her concept of “paracontent,” where the conversation around a phenomenon can become much larger than the phenomenon itself, and what social media data can tell us about how these trends move from niche communities into the mainstream.

They also trace the much longer history of body optimization, from changing ideals of thinness to the rise of the quantified self, and ask what comes next as technology gives people increasingly granular ways to measure and modify themselves. Ruby’s prediction: rather than everyone optimizing toward the same ideal, we may see increasingly individualized and sometimes extreme forms of “body futurism.”


Resources:

Follow Ruby Justice Thelot on X: https://x.com/being_on_line

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Read Ruby’s piece “Enshittification” Isn’t Real: https://www.a16z.news/p/enshittification-isnt-real


 

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Sep 14 2026 | 00:51:02

Ben Horowitz and Erik Torenberg sit down with OpenAI co-founder and President Greg Brockman to discuss why he believes AI has entered a new phase, what OpenAI’s latest models reveal about the path to AGI, and the safety and security challenges that come with increasingly capable systems.

Greg explains why computer use represents such an important step for agents, including models that can work coherently for 24 hours and interact with software through the same interfaces humans use. He also shares how OpenAI deployed 10,000 agents to tackle the Navier-Stokes problem, and why advances in mathematical reasoning could translate into new approaches to science, software, and cybersecurity.

Ben, Erik, and Greg also dig into the “defender’s window” for cybersecurity, how AI could reshape work and entrepreneurship, and what the AI assistant of the future might actually look like: persistent, proactive, personalized, and capable of doing work on your behalf rather than waiting for another prompt.


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Sep 13 2026 | 00:23:30

World Labs co-founder Justin Johnson joins MTS hosts Theo Jaffee and Sofia Puccini to discuss Atlas, World Labs’ latest world model, and the broader case for AI systems that understand and interact with the physical world.

Justin explains how Atlas approaches three core tasks: generating new worlds, reconstructing real environments from images, and simulating how objects or robots might behave within them. Underlying it is a bigger thesis: just as language models became general-purpose engines for working with text, world models could become a horizontal layer for visual and physical intelligence across industries from entertainment and gaming to construction and robotics.

They also explore how world models could change video games and creative tools, why precise spatial control matters, and the potential for “real-to-sim-to-real” robotics, where a few photos of a physical environment could eventually be enough to build a simulation and adapt a robot to that specific space.


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Sep 12 2026 | 01:18:04

a16z General Partner Anish Acharya joins Lenny Rachitsky on Lenny’s Podcast to discuss why fears of an AI-driven “permanent underclass” may be misplaced, how AI is changing the way companies operate, and why the opportunity may be less about replacing people and more about dramatically expanding what they can build.

Anish lays out his idea that companies are becoming a series of loops, with agents increasingly handling workflows across engineering, sales, marketing, support, and other functions while humans provide the judgment and new ideas needed to move beyond local maxima.

They also explore why Anish thinks consumer AI should focus less on productivity and more on helping people live richer lives, why moats are often discovered rather than designed, how to develop intuition for different AI models, and why his biggest advice for anyone trying to keep up with AI is simple: make more things.


Resources:

Follow Anish Acharya on X: https://x.com/illscience

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Read/listen to the original episode on Lenny’s Newsletter:
Why companies are becoming a series of loops | Anish Acharya (a16z)

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Sep 11 2026 | 00:38:05

a16z’s Matt Perault sits down with General Partner and Speedrun lead Andrew Chen on the a16z AI Policy Brief to explore what “Little Tech” actually looks like at the earliest stages, and why the realities of building a two- or three-person startup are often missing from policy debates.

Andrew takes us inside Speedrun, where founders are often starting companies from kitchen tables, working with tiny teams, and trying to determine in a matter of months whether their idea can become a viable business. He explains why these founders rarely have the time or resources to engage with policymakers, even as regulation can have an outsized impact on whether and where they build.

Matt and Andrew also discuss how regulatory burdens accumulate for young companies, why startups can choose where to put down roots, the role of ecosystems like Tech Week, and what policymakers can do to hear directly from the founders who may otherwise be absent from the conversation.

This episode originally appeared on the a16z AI Policy Brief.

 

Resources:

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Learn more about a16z Speedrun: https://speedrun.a16z.com

Listen to more from the a16z AI Policy Brief: https://a16zpolicy.substack.com/
 

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Sep 10 2026 | 00:49:23

a16z’s Jen Kha and David George sit down with Accolade Partners’ Aram Verdiyan to discuss how AI is changing the power law of technology investing, why the largest companies can compound advantages in ways that weren’t possible before, and what that means for how investors construct portfolios.

They explore why AI may be much bigger than traditional software, with applications reaching into labor, healthcare, transportation, services, and other major parts of the economy. David explains why capital itself can now reinforce an AI company’s advantage by buying more compute, while Aram makes the case that AI should increasingly be treated as a core allocation rather than a satellite position.

The conversation also gets into the changing economics of venture and growth investing, how to distinguish real AI traction from early hype, what AI means for legacy software and private equity, and why some of the largest opportunities may still be ahead in robotics, autonomy, healthcare, energy, and physical infrastructure.


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Sep 09 2026 | 00:39:45

a16z’s Erik Torenberg, Ben Horowitz, and Jennifer Li sit down with Vals founder and CEO Rayan Krishnan to discuss one of AI’s increasingly difficult problems: how do you actually measure whether a model is getting better?

As public benchmarks saturate and models get better at optimizing for the tests themselves, Rayan makes the case for independent, continuously evolving evaluations. They unpack why self-reported model scores can be misleading, how VALS evaluates models in the hours before a release, and why measuring increasingly agentic systems means testing work that can unfold over hours, days, or even weeks.

They also explore why evals are becoming critical for enterprises trying to understand the ROI of AI, what happens if token spend begins to rival employee salaries, and how evaluations could eventually provide a shared language for everything from model routing and recursive self-improvement to AI policy and international coordination.


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Follow Rayan Krishnan on X: https://x.com/RayanKrishnan

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Sep 08 2026 | 01:05:15

a16z Infra Partner Lisha Li sits down with OpenAI mathematicians Mehtaab Sawhney and Mark Sellke to discuss how quickly AI’s mathematical capabilities are advancing, what recent results reveal about model reasoning, and what happens when AI begins making progress on problems mathematicians have struggled with for decades.

Mehtaab and Mark unpack several recent results from OpenAI’s models, including advances in sphere packing and the construction of a non-sofic group. They explain why the surprising part isn’t simply that models can search more possibilities or work longer than humans: in many cases, the reasoning traces look remarkably similar to the work of an expert mathematician, including choosing promising approaches, backtracking when they fail, and combining ideas from across the literature.

They also explore what this means for mathematics itself: how the role of human taste and judgment may change, whether AI could produce far more mathematics than humans can absorb, and why models that accelerate discovery may also make sophisticated results easier to understand.


Resources:

Follow Lisha Li on X: https://x.com/lishali88

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Sep 07 2026 | 00:08:05

MTS host Sophia Dew visits the Open Source AI Summit in San Francisco to ask researchers and founders across the AI stack a central question: can open source prevent AI power from concentrating in the hands of a few companies?

Lukasz Kaiser, co-author of Attention Is All You Need, argues that today’s concentration may be a feature of the current technological paradigm rather than a permanent feature of AI. Transformers reward enormous amounts of data and compute, but future breakthroughs could make smaller, more specialized models far more capable.

Across conversations with researchers and builders working on open models, infrastructure, and applications, Sophia explores why China has taken the lead in open-weight models, whether the U.S. needs more open-model startups, what it means for companies to own their own intelligence, and where openness alone falls short, particularly when access to compute remains concentrated.

 

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Follow Lukasz Kaiser on X: https://x.com/lukaszkaiser

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Sep 06 2026 | 00:27:30

a16z General Partner Julie Yoo joins MTS host Sophia Dew to explain why she believes healthcare could benefit more from AI than almost any other industry, and why decades of slow technology adoption may actually give healthcare an advantage in the AI era.

Julie traces healthcare’s evolution from paper records and fax machines through electronic health records and telehealth, and explains why AI represents something different: an organic adoption wave driven by tools that doctors and patients actually want to use. Because healthcare never built the same layers of legacy software as other industries, it may now be able to leapfrog directly into agentic AI.

They also explore how AI could dramatically lower the cost of care, why consumers are becoming a more important payer, where Julie sees the biggest opportunities for healthcare founders, and a future where everyone has a highly personalized AI doctor in their pocket for life.


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Sep 05 2026 | 00:31:05

Box co-founder and CEO Aaron Levie joins MTS hosts Theo Jaffee and Sofia Puccini to make the case for open-weight AI, unpack the economics of open versus closed models, and explain why he believes more openness could strengthen rather than undermine the U.S. AI ecosystem.

Aaron argues that open models create more use cases, push closed labs to innovate faster, and don't fundamentally change where the economics of AI ultimately accrue. They debate model distillation, America's competition with China, why restricting access may simply accelerate competing AI ecosystems, and whether U.S. labs should begin releasing open-weight versions of previous-generation models.

They also get into what the latest frontier models mean for knowledge work, how AI has changed software engineering at Box, and why Aaron believes companies cutting engineers may simply not be ambitious enough. Finally, they discuss why enterprises are unlikely to bet on a single model and why the layer that routes between models, data, and workflows could become increasingly valuable.

 

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Sep 04 2026 | 00:44:36

World Labs co-founders Fei-Fei Li, Justin Johnson, and Ben Mildenhall join a16z General Partner Martin Casado to discuss Atlas, their latest world model, and what it reveals about the pursuit of spatial intelligence.

At the center of Atlas is what the team calls “new view prediction”: given images or views of a scene, the model predicts what that environment should look like from a different position in space and time. This brings generation and 3D reconstruction into the same model, and raises a broader question about whether predicting views could become a useful primitive for understanding the physical world.

They discuss the technical bets behind the model, what it can and can’t yet capture, and the importance of dynamics, editability, and simulation as world models develop. The conversation also explores applications in creative work, architecture, and robotics, where Fei-Fei argues that one of today’s biggest constraints is access to real-world training data.

 

Resources:

Follow Fei-Fei Li on X: https://x.com/drfeifei

Follow Justin Johnson on X: https://x.com/jcjohnss

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Learn more about Atlas: https://www.worldlabs.ai/blog/atlas



 

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